Cerebrovasculature in AD and Dementia
Disturbances in the cerebrovascular system, including hypoperfusion and loss of blood-brain barrier (BBB) integrity, likely contribute to Alzheimer's disease (AD) pathogenesis and cerebral amyloid angiopathy (CAA), which often coexists with AD. Importantly, APOE4 is a strong genetic risk factor for both AD and CAA. While it is increasingly recognized that apoE plays a critical role in multiple biological processes necessary for maintaining central nervous system homeostasis, the cerebrovascular effects of apoE are not fully understood.
Dr. Bu's lab is focused on defining the cerebrovascular effects of apoE isoforms to explore the potentials of apoE- and vascular-targeted therapies for AD and aging-related cognitive decline.
Studies in the Neurobiology of Alzheimer's Disease Lab aim to determine the effects of apoE isoforms on maintaining cerebrovascular homeostasis and the metabolism of amyloid-beta. Toward this, the lab takes advantage of multiple disease modeling systems. These include human iPSC-derived vascular cells, in vitro BBB and 3D vessel models, unique animal models, and postmortem human brain tissues.