Dr. Bu has published numerous scientific articles about his research in the Neurobiology of Alzheimer's Disease Laboratory, including papers on genetic and clinical investigations of TREMS, amyloid pathology and accumulation of amyloid B-42 in Alzheimer's disease, inflammatory responses in microglia and other research in Alzheimer's disease.

See a list of Dr. Bu's publications.

Recent key publications

Liu CC, Zhao N, Fu Y, Wang N, Linares C, Tsai CW, Bu G. ApoE4 Accelerates Early Seeding of Amyloid Pathology. Neuron. 2017, Dec 6;96(5):1024-1032.e3.

Shinohara M, Koga S, Konno T, Nix J, Shinohara M, Aoki N, Das P, Parisi JE, Petersen RC, Rosenberry TL, Dickson DW, Bu G. Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-β42 in Alzheimer's disease. Brain. 2017 Dec 1;140(12):3301-3316.

Zhao N, Liu CC, Van Ingelgom AJ, Martens YA, Linares C, Knight JA, Painter MM, Sullivan PM, Bu G. Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. Neuron. 2017 Sep 27;96(1):115-129.e5.

Zhao N, Liu CC, Qiao W, Bu G. Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease. Biol Psychiatry. 2017 Mar 14. pii: S0006-3223(17)31358-6.

Zhong L, Chen XF, Wang T, Wang Z, Liao C, Wang Z, Huang R, Wang D, Li X, Wu L, Jia L, Zheng H, Painter M, Atagi Y, Liu CC, Zhang YW, Fryer JD, Xu H, Bu G. Soluble TREM2 induces inflammatory responses and enhances microglial survival. J Exp Med. 2017 Mar 6;214(3):597-607.

Liu CC, Zhao N, Yamaguchi Y, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G. Neuronal heparin sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease. Science Translational Medicine. 2016;8:332ra44.

Shinohara M, Kanekiyo T, Yang L, Linthicum D, Shinohara M, Fu Y, Price L, Frisch-Daiello JL, Han X, Fryer JD, Bu G. APOE2 eases cognitive decline during aging: Clinical and preclinical evaluations. Annals of Neurology. 2016;79:758.

Liu CC, Hu J, Tsai CW, Yue M, Melrose HL, Kanekiyo T, Bu G. Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain. The Journal of Neuroscience. 2015;35:5851.

Liu CC, Tsai CW, Deak F, Rogers J, Penuliar M, Sung YM, Maher JN, Fu Y, Li X, Xu H, Estus S, Hoe HS, Fryer JD, Kanekiyo T, Bu G. Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease. Neuron. 2014;84:63.

Kanekiyo T, Xu H, Bu G. ApoE and Aβ in Alzheimer's disease: Accidental encounters or partners? Neuron. 2014;81:740.

Kanekiyo T, Cirrito JR, Liu CC, Shinohara M, Li J, Schuler DR, Shinohara M, Holtzman DM, Bu G. Neuronal clearance of amyloid-β by endocytic receptor LRP1. The Journal of Neuroscience. 2013;33:19276.

Liu CC, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer's disease: Risk, mechanisms, and therapy. Nature Reviews Neurology. 2013;9:106.