Extracellular Vesicles for Immunomodulation

How extracellular vesicles are biological nanoparticles that contain biomolecules, such as RNAs and proteins

Extracellular vesicles are biological nanoparticles that contain biomolecules, such as RNAs and proteins.

Extracellular vesicles (EVs) are biological nanoparticles secreted by all cells. Extracellular vesicles contain biomolecules, such as RNA, proteins, lipids and carbohydrates, which play an important role in cell communication.

Recent evidence suggests that the beneficial effects of stem cells in suppressing inflammation are largely due to paracrine effects mediated by extracellular vesicles.

Our lab studies the effect of extracellular vesicles on inflammation and uses novel methods for extracellular vesicle isolation from cell culture media and biological fluids.

One major focus of Dr. Wolfram's research team is using extracellular vesicles to treat cardiovascular diseases. The National Institutes of Health, the Center for Regenerative Medicine at Mayo Clinic and the Eagles Cancer Telethon support Dr. Wolfram's research efforts. Our lab is also focused on developing scalable manufacturing processes for bringing stem cell-derived extracellular vesicles to clinical practice.