Final preparation of cyclotron-produced 68Ga-PSMA-CC for PET-CT imaging for human study in a clean room.
Molecular imaging in the laboratory concentrates on research and clinical diagnostics in the following focus areas:
- Radioisotope production. Looks at developing cyclotron targetry to produce radiometals for radiolabeling of radiopharmaceuticals.
- Radiochemistry and automation. Supports the development of radiochemistry instrumentation and methods to support novel development of radiopharmaceuticals.
- Radiometals in Alzheimer's disease. Analyses positron emission tomography (PET)-related radiometal approaches to studying the changes in metal disposition with Alzheimer's disease and correlation of these changes with known interactions with beta-amyloid plaque depositions.
- Fatty acid metabolism in heart and metabolic disorders. Investigates the development and use of fluorine-18-labeled fatty acid analogs to study fatty acid oxidation in cardiovascular diseases and metabolic disorders, such as diabetes.
- Sodium iodide symporter (NIS) imaging. Studies the development and use of fluorine-18-labeled tetrafluoroborate (TFB) and TFB analogs as PET probes to evaluate thyroid cancer and gene reporter probe for therapeutic viruses carrying the NIS gene.
- Imaging of brain biochemistry in psychiatric disorders. Examines the use of metabolic imaging of neurochemical systems to understand disease pathology and predict and monitor treatment response.
- Imaging and theranostics in glioblastomas. Pairs biomarkers of tumor aggressiveness with relevant treatment paradigms to improve treatment planning and monitoring of tumor response.
- Noninvasive cell tracking methods. Aims to develop new methods to label and image cells (stem cells, dendritic cells and others) for the purpose of noninvasive monitoring of cell transport and survival.