Role of circadian disruption in pathophysiology of obesity and diabetes

Conditions associated with circadian disruption, such as shift work and sleep loss, are increasingly common in today's society and increase susceptibility for development of obesity, metabolic syndrome and diabetes. Mechanisms responsible for these associations remain unknown. The work in the Islet Regeneration lab is focused on elucidating physiological and molecular links that drive driving the association between circadian disruption and loss of glycemic control, with particular focus on regulation of beta cell function and survival.