Capturing and Disseminating PGx CDS Knowledge

While all medical centers use the same body of knowledge to inform the design of pharmacogenomic (PGx) clinical decision support (CDS), no two implementations are the same. Sharing detailed information about PGx CDS implementations is critical to establishing standards of care and enabling multi-site outcomes studies, yet no conventions exist. In fact, one of the greatest challenges in comparing PGx CDS rules is unambiguously documenting how a genetic test result is generated, interpreted, and acted upon clinically. In partnership with the Pharmacogenomics Research Network Translational Pharmacogenetics Project (PGRN-TPP), the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the eMERGE Network, we are developing novel methods for capturing PGx CDS knowledge and creating public repositories for sharing.