Staphylococcus lugdunensis Biofilm Formation

S. lugdunensis is a recently described coagulase negative Staphylococcus species that has been determined by our group and others to be a virulent human pathogen, capable of causing diseases more akin to Staphylococcus aureus than a typical coagulase negative Staphylococcus species (e.g., native valve endocarditis). This suggests that this species has unique characteristics differentiating it from other coagulase negative Staphylococcus species. The types of infection caused by S. lugdunensis, supported by data generated in our laboratory demonstrating the ability of this organism to form biofilm, suggest that biofilm formation contributes to this species' virulence.

We have identified a locus with homology to the S. aureus and Staphylococcus epidermidis ica loci in S. lugdunensis. Interestingly, S. lugdunensis forms biofilm, but its biofilm extracellular matrix is predominantly proteinaceous. Understanding the mechanisms of biofilm formation in S. lugdunensis should enable new, more effective and targeted preventive and therapeutic interventions to meet the challenges of biofilm-related infections, including endocarditis and prosthetic joint infection.