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Laboratories

Experimental Drug and Therapeutics for Pediatric Brain Tumor: David J. Daniels

  • About
    • About
    • About the Lab
    • Faculty and Staff
  • Research Activities
    • Research Activities
    • STAT3 Pathway Protein Inhibitors
    • Histone Mutation and Tumor Development in DIPGs
    • Glutamine Metabolism in High-Grade Gliomas
    • Therapeutic Vulnerabilities in DIPGs
    • Convection-Enhanced Delivery
    • Funding
  • Publications
  • Contact

Development of Novel STAT3 Inhibitors That Target Malignant Brain Tumors

The Experimental Drug and Therapeutics for Pediatric Brain Tumor Lab is looking at the STAT3 pathway as a new therapeutic target for treating malignant brain tumors.

STAT3 protein pathway inhibitors

Histone Mutation and Tumor Development in Diffused Intrinsic Pontine Gliomas

The goal of this project is to develop new drugs and therapies for children with DIPGs by understanding the role of histone mutation in DIPG tumor cells.

Histone mutation and tumor development in DIPG

Evaluating Glutamine Metabolism in Pediatric High-Grade Gliomas With the H3K27M Mutation

Dr. Daniels' team is discovering that regulating glutamine metabolism may represent a new therapeutic approach for gliomas with this mutation.

Glutamine metabolism in high-grade gliomas

Evaluating Therapeutic Vulnerabilities in DIPG Tumors Using High-Throughput Screening

The Experimental Drug and Therapeutics for Pediatric Brain Tumor Lab is identifying drugs for rapid clinical translation to develop molecularly targeted therapies for DIPG.

Therapeutic vulnerabilities in DIPG

Convection-Enhanced Delivery — Overcoming the Bottleneck in Brain Drug Development

Dr. Daniels' lab is studying the feasibility of using convection-enhanced delivery to bypass the blood-brain barrier and distribute drugs directly to a target region.

Convection-enhanced delivery

Funding

Funding for Dr. Daniels' pediatric brain tumor research comes from the National Institutes of Health, the National Cancer Institute and Mayo Clinic.

Funding
.

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