The Cholangiopathies Laboratory of Mayo Clinic researcher Nicholas F. LaRusso, M.D., focuses on cholangiocyte pathobiology. Cholangiocytes — epithelial cells that line intrahepatic bile ducts — have biological and clinical importance in liver disease.

The objective of Dr. LaRusso's Cholangiopathies lab is to apply the fundamental concepts and broad technologies of cell and molecular biology to understand cholangiocyte function and dysfunction. The Cholangiopathies lab at Mayo Clinic has played a pivotal role in advancing cholangiocyte pathobiology by developing novel hypotheses and new techniques, such as exosome isolation, bile duct perfusion, cholangiocyte and cilia isolation, and cysts grown in 3-D culture.