Overview

As principal investigator in the Cell and Molecular Biology of Carcinogenesis Laboratory, Nicole R. Murray, Ph.D., is advancing knowledge about the molecular mechanisms behind the initiation and progression of pancreatic cancer. Dr. Murray's goal is to promote the development of new treatment options for pancreatic cancer, including pancreatic ductal adenocarcinoma.

Our lab uses a combination of cellular and molecular biology techniques and transgenic and tumor mouse models to identify, characterize and inhibit the signaling pathways that may contribute to the progression of pancreatic cancer. We're investigating the role of atypical protein kinase C in the development and maintenance of pancreatic ductal adenocarcinoma and characterizing atypical protein kinase C as a potential therapeutic target for the treatment of pancreatic cancer.

Our lab is also developing new preclinical models for a more individualized approach to the development and screening of experimental therapeutics. The goals of these studies are to evaluate chemotherapy sensitivity and guide the selection of chemotherapy for patients with pancreatic cancer.

About Dr. Murray

Dr. Murray is an associate professor of cancer biology and an assistant professor of pharmacology at Mayo Clinic College of Medicine and Science in Jacksonville, Florida. Dr. Murray's research focuses on the pathways involved in the initiation and progression of cancer, with a particular emphasis on pancreatic cancer and the development of new screening methods and treatment options to improve outcomes for patients with pancreatic cancer.