Vascular Abnormalities in Polycystic Kidney Disease

The overall aim of this research project is to investigate vascular abnormalities in polycystic kidney disease.

Our lab uses state-of-the-art imaging modalities, including micro-CT, micro-ultrasound and optical molecular imaging, to verify the hypothesis that vascular abnormalities are a primary problem in PKD.

Polycystic kidney disease is the most common inherited renal cystic disease. It's characterized by renovascular and renal tubular derangements, with no effective and approved therapy. Read more about polycystic kidney disease.

Our goal is to develop novel therapeutic targets that can lead to better interventions to restore renal function and structure in PKD. The potential new interventions we're developing may also complement others currently under investigation.

Our lab works in close collaboration with the Mayo Clinic Robert M. and Billie Kelley Pirnie Translational Polycystic Kidney Disease (PKD) Center. We also work with Vicente E. Torres, M.D., Ph.D., and Peter C. Harris, Ph.D., both nationally and internationally recognized experts in PKD. These close collaborations ensure that this project is incorporated with other scientific advancements in the field.