Overview

The Cardiovascular Genetics Laboratory studies the important role that hereditary factors play in the development and progression of cardiovascular diseases.

Guided by physician-scientist Timothy M. Olson, M.D., the lab's research team is investigating genetic variants that cause or confer susceptibility to heart and blood vessel disorders in otherwise healthy children and young adults.

Our work focuses on family-based experimental strategies, including genetic linkage analysis to map the genomic location of novel disease genes, whole-exome and -genome sequencing, and hypothesis-based mutation scanning of candidate genes.

New hope for patients

Particular areas of research include conditions that can have devastating effects and often require heart transplant, such as dilated cardiomyopathy, hypoplastic left heart syndrome (HLHS) and spontaneous coronary artery dissection (SCAD). Our long-term objective is to decipher the underlying molecular mechanisms of idiopathic cardiovascular disorders and apply this knowledge to the development of new diagnostic and therapeutic solutions for patients and their families.

About Dr. Olson

Dr. Olson is a pediatric cardiologist at Mayo Clinic in Rochester, Minnesota, who treats dilated cardiomyopathy, hypoplastic left heart syndrome and spontaneous coronary artery dissection. Dr. Olson is also a professor of medicine and a professor of pediatrics at the Mayo Clinic College of Medicine and Science. He is also on the leadership team of the Todd and Karen Wanek Family Program for Hyoplastic Left Heart Syndrome (HLHS) at Mayo Clinic, serving as director of human genetics.