Research

The Cardiovascular Epidemiology and Outcomes Laboratory has several ongoing research projects and studies, including research on atrial fibrillation, a DNA biobank, heart failure, atherosclerosis and heart attack.

  • Atrial fibrillation. This study describes trends in atrial fibrillation incidence, treatment and survival. It investigates the impact of rate versus rhythm control on overall survival and stroke-free survival within a community-based setting, where the clinical management of atrial fibrillation is not randomized.
  • Cardiovascular Disease Specimen Repository. This study maintains a DNA biobank of consenting patients from cohorts with myocardial infarction and heart failure. Prospective recruitment is ongoing for eligible patients with suspected heart disease for genetic studies with subsequent clinical validation of disease status.
  • Heart failure. This research study examines the incidence and outcomes of heart failure within a community-based setting. In particular, the study focuses on describing the epidemic of hospitalizations occurring in patients with heart failure by investigating causes of frequent hospitalizations and other health care utilization.
  • Multiscale biology of atherosclerosis in the cellular adhesion pathway. This project is a substudy of the Multi-Ethnic Study of Atherosclerosis (MESA) study. The goal is to investigate the biological interactions and regulation of cellular adhesion pathway components to improve understanding of these mechanisms on subclinical atherosclerotic disease.
  • Myocardial infarction. This study uses community surveillance to investigate the incidence and outcomes of coronary disease, including both heart attack (myocardial infarction) and unstable angina.