Image of Jordan D. Miller, Ph.D., of the Cardiovascular Disease and Aging Lab at Mayo Clinic Innovating new heart disease therapies

Dr. Miller's lab studies and develops new therapies for aortic valve disease, mitral valve disease and other heart diseases. Our lab is dedicated to moving research findings from bench to bedside as rapidly as possible to improve medication and surgery options.


The Cardiovascular Disease and Aging Laboratory of Jordan D. Miller, Ph.D., researches mechanisms that contribute to age-related cardiovascular diseases, with a goal of developing better treatments.

Our main research includes:

  • Mechanisms that contribute to cardiovascular stiffening and calcification that come with aging, including calcification of the aortic valve and large arteries.
  • Mechanisms that contribute to vascular and endothelial dysfunction.
  • Mechanisms that contribute to mitral valve prolapse and regurgitation.
  • The effects of heart valve dysfunction on cardiac muscle.

We use insights from these mechanistic studies to develop novel pharmacotherapies aimed at slowing, halting and reversing disease progression.

Our secondary research centers on developing, testing and implementing innovative technologies in surgical practices at Mayo Clinic.

To help identify novel mechanisms of disease, we use molecular screening of human tissue, novel strains of genetically altered animal models, and in vitro and cell culture models of disease. Our achievements are enabling us to advance novel therapeutic approaches through phase 1 and phase 2 clinical trials aimed at improving outcomes in cardiovascular disease.

The overarching goal of all of our research efforts is to create innovative solutions that improve patient care with both medicines and technology.

Read more about our research focus areas.

About Dr. Miller

In addition to serving as principal investigator of the Cardiovascular Disease and Aging Lab, Dr. Miller is an associate professor of surgery and an assistant professor of physiology and biomedical engineering at Mayo Clinic College of Medicine and Science in Rochester, Minnesota. Dr. Miller also serves as vice chair for research in the Department of Cardiovascular Surgery in Rochester. Dr. Miller's multidisciplinary collaborations throughout Mayo Clinic have helped with the identification of multiple novel contributors to age-related diseases and the successful launch of numerous clinical trials for drugs and devices. Read Dr. Miller's research biography.