The Cancer Genomics Laboratory of Zhaoyu Li, Ph.D., at Mayo Clinic in Jacksonville, Florida, investigates genetic and epigenetic mechanisms of tissue-specific gene regulation during cancer progression, tissue development and stem cell differentiation.

Our team also conducts related studies on cancer therapeutics, and we're performing a comparative genomics study between liver cancer and breast cancer.

Our cancer genomics study involves comparing the dual regulation of transcription factors Forkhead box A (Foxa) and estrogen receptor alpha (ERalpha) between liver cancer and breast cancer in both animal models and human tumors. The study is accomplished using genomic and proteomic approaches, including next-generation sequencing and mass spectrometry.

We're translating results from our studies into researching human cancer and testing target genes for therapeutics for both liver cancer and breast cancer.

Next-generation sequencing technology allows Dr. Li's research team to reveal detailed chromatin structures in the whole genome, which provides novel scenarios of gene regulation compared with traditional approaches.

The Cancer Genomics Lab is also conducting research to identify the genomic and epigenomic landscapes in regulating stem cell differentiation and their impact on cancer progression using genomic and bioinformatics approaches.


Research collaborations can help advance scientific discovery. Our lab is affiliated with several other research areas at Mayo Clinic to help advance our cancer research:

About Dr. Li

In addition to serving as principal investigator of the Cancer Genomics Lab, Dr. Li is an assistant professor of cancer biology at Mayo Clinic College of Medicine and Science in Jacksonville, Florida. Dr. Li hopes that his research will not only address fundamental questions in cancer biology but also benefit cancer diagnosis and treatment.