Transcription Coregulators in Prostate Tumorigenesis

Prostate tumorigenesis research in Dr. Huang's Cancer Epigenetics and Functional Genomics Lab at Mayo Clinic is designed to understand how loss or overexpression of transcription coregulatory factors works synergistically with loss of tumor suppressor genes such as PTEN or SPOP to drive prostate cancer development and progression.

Transcription coregulator molecules are important for transcription factor-initiated gene transcription. Because the function of transcription coregulators is often dysregulated in human prostate cancer, Dr. Huang's research team takes a gene knockout approach to investigate how loss of transcription coregulators such as CBP and p300 impacts prostate tumorigenesis and prostate cancer progression and metastasis.

Findings from these studies will not only enhance the understanding of the etiology of prostate cancer but also could lead to identification of new targets for better diagnosis and treatment.

The lab's project on transcription coregulators in prostate tumorigenesis is supported by Mayo Clinic institutional funds.