Genetic Epidemiology of Non-Hodgkin Lymphoma Study

The Genetic Epidemiology of Non-Hodgkin Lymphoma (GEN) Study is a family-based observational study investigating genetic origins of non-Hodgkin lymphoma (NHL, also called non-Hodgkin's lymphoma).

Although non-Hodgkin lymphoma is known to be influenced by immunosuppression and viral infection agents (established risk factors), in the majority of cases, the etiology can't be explained.

There is significant evidence that a genetic component exists and that this genetic component extends across all subtypes of non-Hodgkin lymphoma.

The overall aim of the Genetic Epidemiology of Non-Hodgkin Lymphoma Study is to investigate the genetic basis of non-Hodgkin lymphoma through the participation of high-risk NHL families.

This family-based research resource allows Dr. Slager's B-Cell Lymphoproliferative Disorders Lab to develop a study population enriched for genetic exposures, positioning the research team to characterize the genetic risk of non-Hodgkin lymphoma.

Study eligibility

To join the study, a family must have:

  • A living patient diagnosed with NHL
  • A living blood relative diagnosed with NHL

Study requirements

Families interested in the Genetic Epidemiology of Non-Hodgkin Lymphoma Study don't need to visit a study site to participate. The study pays for any costs associated with participation, including blood draws and samples, and sends related questionnaires.

Patients who consent to participate will be asked to:

  • Complete a questionnaire detailing the family history of cancer.
  • Complete a questionnaire about lifestyle factors, personal medical history and demographic information.
  • Donate a blood sample, a saliva sample or both. You can provide this sample during a visit to a participating institution or via a mailed kit that you can take to your local clinic or doctor.