Led by principal investigator Juraj Sprung, M.D., Ph.D., the Anesthesia Outcomes Laboratory at Mayo Clinic studies factors that affect perioperative outcomes, especially in patients at higher risk of complications or those with medical conditions that can lead to adverse outcomes.

Respiratory complications play a significant role in postoperative outcomes. Patients at high risk — such as older adults, patients with morbid obesity, or patients undergoing prolonged thoracic, vascular and upper abdominal procedures — have an increased incidence of pulmonary complications after surgery. Emerging evidence shows that conventional ventilator settings during anesthesia in these patients may be associated with increased incidence of acute ventilator-associated lung injury and respiratory failure.

Our lab researches the association between various ventilatory strategies and pulmonary complications in older patients and those with morbid obesity. In addition, we conduct a variety of retrospective studies to evaluate anesthesia-relevant outcomes.

Particular areas of research interest include:

  • Mode of ventilation and acute lung injury
  • Effects of lung recruitment on uptake of inhalational anesthetics
  • Pharmacological therapy of postoperative nausea and vomiting
  • Anesthesia outcome studies
  • Clinical pharmacology studies relevant to anesthesia

Dr. Sprung's research in the Anesthesia Outcomes Lab enables anesthesia providers to be proactive in the face of potential rare adverse events. His work also helps patients in their decision-making when choosing elective surgery, especially for older adults with concerns about anesthesia and possible links to Alzheimer's disease or dementia.

Research affiliations

Our lab is affiliated with these Mayo Clinic research groups:

About Dr. Sprung

Dr. Sprung is an anesthesiologist at Mayo Clinic in Rochester, Minnesota, and a professor of anesthesiology in the Mayo Clinic College of Medicine and Science. Dr. Sprung studies rare medical conditions and perioperative outcomes in order to identify modifiable factors and thus reduce the number of perioperative complications.

More about Dr. Sprung