Genome-guided breast cancer study may lead to customized treatment

Volume 1, Issue 1, 2012
Matthew P. Goetz, M.D.

Matthew P. Goetz, M.D.

Oncologists, surgeons, radiologists, and genomics and cancer researchers will work together to uncover the clues to effective individualized therapies and drug discovery. "We are living in an era that I never thought I'd see during my career — when we can sequence, in real time, the entire genome of a patient and her tumor and use that information to tailor treatment to the individual patient," said Richard Weinshilboum, M.D., director of the Pharmacogenomics Program in the Mayo Clinic Center for Individualized Medicine and the Mary Lou and John H. Dasburg Professor of Cancer Genomics.

Together, the whole-genome sequencing data and transplanted cell lines are used to identify the gene pathways that influence a patient's responses to chemotherapy. Armed with this deeper understanding of the genomics of cancer, doctors will be able to optimize treatment plans for individual patients.

Though initially being applied to breast cancer, this approach is also being used to study the treatment of many other types of cancer.

The BEAUTY Project is funded by Mayo Clinic benefactors and the Mayo Clinic Center for Individualized Medicine. For information about cancer clinical trials at Mayo Clinic, call 507-538-7623.