Rochester, Minnesota Clinical Profile


The research of William J. Tremaine, M.D., focuses on the clinical aspects of inflammatory bowel disease (IBD), including ulcerative colitis, Crohn's disease, ileal pouchitis and microscopic colitis.

Dr. Tremaine is interested in the natural history, epidemiology, diagnostic studies, and medical and surgical therapy of these diseases. He works in collaboration with colleagues in the Mayo Clinic Comprehensive Cancer Center to study the increased risk of cancer in patients with longstanding IBD and due to immune therapy for IBD.

Focus areas

  • Clinical care of patients with Crohn's disease, ulcerative colitis and microscopic colitis
  • Research on the natural history and clinical characteristics of IBD
  • Research on ethical issues in the care of patients with IBD

Significance to patient care

Dr. Tremaine is currently interested in the role of pelvic floor dysfunction in the symptoms experienced by patients with Crohn's disease and ulcerative colitis, and those who have undergone ileal pouch-to-anal anastomoses.

He's also interested in the natural history of patients with upper gastrointestinal tract Crohn's disease and identifying best management practices for that group.

Professional highlights

  • Chair, Clinical Research Grants Committee, Crohn's and Colitis Foundation of America, 2011-present
  • Chair, Evaluation Meeting for the National Institute of Diabetes and Digestive and Kidney Disease Inflammatory Bowel Disease Genetics Consortium, 2011
  • Distinguished Clinician Award, American Gastroenterological Association, 2011
  • Maxine and Jack Zarrow Family Professor of Gastroenterology Specifically for IBD, 2008
  • Section Editor, Inflammatory Bowel Diseases


Primary Appointment

  1. Consultant, Division of Gastroenterology and Hepatology, Department of Internal Medicine

Academic Rank

  1. Professor of Medicine


  1. Fellow - Gastroenterology Mayo Graduate School of Medicine, Mayo Clinic College of Medicine
  2. Resident Mayo Graduate School of Medicine, Mayo Clinic College of Medicine
  3. MD University of Mississippi, Jackson
  4. BA Vanderbilt University

Clinical Studies

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