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Organ fibrosis results in a loss of normal tissue architecture and function and is accompanied by a combination of disrupted cell-cell interactions, adoption of abnormal cell fates and a scarred fibrotic matrix. The research of Qi Tan, Ph.D., focuses on lung fibrosis and lung regeneration.
Dr. Tan's lab is leveraging novel mouse models, lung organoids and next-generation sequencing as tools to understand epithelial-mesenchymal interactions in lung fibrosis. His long-terms goals are to redirect the fate of diseased cells during fibrosis using CRISPR activation and small-molecule therapeutics, leading to the development of novel regenerative therapies.
Organ fibrosis results in a great deal of morbidity and mortality due to diseases such as idiopathic pulmonary fibrosis (IPF). The increasing clinical need underscores the urgency of better understanding IPF pathology and developing novel therapies. Dr. Tan's research program aims to delineate epithelial-mesenchymal homeostatic signals and cellular plasticity during fibrosis and repair. The long-term goal is to develop new regenerative therapeutic strategies with a focus on augmenting the lung's own ability for repair, providing new avenues for organ fibrosis therapy.
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