The laboratory of Adam G. Schrum, Ph.D., is focused on physiologic signaling protein networks and seeks to identify protein-complex signatures that program distinct functional T cell responses in the adaptive immune system. The lab is interested in how the immune system decides whether to destroy or tolerate tissues bearing persistent antigens.
Dr. Schrum's lab first focuses on the T cell antigen receptor and how its structure, multi-subunit composition and biochemical functions operate throughout the course of immune responses. Then the lab studies how the many other proteins and pathways involved in T cell signaling cooperate to compose a network with emergent properties to determine immune fate. Using cellular, molecular, biochemical, and proteomic techniques, the lab examine these processes in T cell responses to tumors and transplanted tissues.
Dr. Schrum and his colleagues recently published a multiplex, microsphere-based approach to generate network-signaling signatures of proteins in shared complexes detected by exposed surface epitopes (PiSCES). The full text of the article is available here.