Rochester, Minnesota




Miguel L. Prieto, M.D., is studying the association between bipolar disorder and cardiometabolic disease, including obesity, metabolic syndrome, cardiovascular disease and stroke. Utilizing a translational approach, Dr. Prieto is focused on a better understanding of the risks of these diseases in populations of patients with bipolar disorder.

In addition, he is interested in identifying genomic and metabolomic biomarkers that predict future development of cardiometabolic disease and the response to certain pharmacological treatments. Dr. Prieto's ultimate goal is to develop interventions that decrease the rates of cardiometabolic disease and subsequent mortality in patients with bipolar disorder.

Focus areas

  • Determining the risk and time course of cardiovascular disease and stroke in patients with bipolar disorder in Olmsted County, Minn., utilizing the Rochester Epidemiology Project
  • Identifying genetic variants and metabolomic biomarkers that are involved in bipolar disorder susceptibility and the subsequent development of cardiometabolic disease
  • Discovering genomic and metabolomic biomarkers of disease susceptibility and treatment response in bipolar depression

Significance to patient care

The main benefit of Dr. Prieto's research is to decrease the likelihood of having a cardiometabolic disease in patients with bipolar disorder. This is accomplished by identifying risk factors and predictive biomarkers of cardiovascular and metabolic illnesses. In addition, identifying biomarkers of treatment response allows clinicians to choose the right treatment that is tailored toward patients with bipolar depression.

Professional highlights

  • Career Development Institute for Bipolar Disorder awardee, National Institute of Mental Health and University of Pittsburgh, 2013
  • Becas Chile Scholarship, University of California, Irvine, 2012-present
  • Treasurer, Chilean Society for Bipolar Disorders, International Society for Bipolar Disorders, 2011-present



  1. BASIC SCIENCE MASTERS Biomedical Sciences, Programs, Mayo Graduate School, Mayo Clinic College of Medicine

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