The primary research interest of Mei-Yin C. Polley, Ph.D., is the conduct and the methodology of clinical trials in cancer. Areas of active research include: design and analysis of biomarker-based clinical trials, innovative group sequential methods for biomarker validation, biomarker reproducibility, and sample size methods for biomarker studies.
Dr. Polley is an associate professor of biostatistics in the Mayo Clinic College of Medicine, and the director of biostatistics, bioinformatics and patient registry core of the Mayo Clinic Breast Cancer Specialized Program of Research Excellence. She is also the lead faculty statistician for the Breast Committee of the Alliance for Clinical Trials in Oncology, the lead faculty statistician for the Cancer Prevention Network and the primary consulting statistician for the Lymphoma Program of the Mayo Clinic Cancer Center.
- Biomarker-based clinical trial designs
- Group sequential methods for biomarker validation
- Biomarker reproducibility
- Dose-finding trials
Significance to patient care
The clinical trials conducted by Dr. Polley could result in new treatment options for patients with cancer. In addition, the research that Dr. Polley is a part of directly results in an increased understanding of cancer and patient factors that make tumors more or less aggressive.
- Associate professor of biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 2016-present
- Director, Biostatistics, Bioinformatics, and Patient Registry Core (the Mayo Clinic Breast Cancer Specialized Program of Research Excellence), 2016-present
- Member, Breast Oncology Local Disease (BOLD) Task Force, Breast Cancer Steering Committee (BCSC), National Cancer Institute, 2016-present
- Member, Pediatric and Adolescent Solid Tumor Steering Committee (PASTSC), National Cancer Institute, 2016-present
- Member, Scientific Program Committee — Biostatistics Track, American Society of Clinical Oncology (ASCO), 2016-present
- Mathematical Statistician, Biometric Research Branch (BRB), Division of Cancer Treatment and Diagnosis, National Cancer Institute, 2010-2015
- Assistant professor, Department of Neurological Surgery, University of California San Francisco, 2007-2010
- Biostatistics manager, Amgen Inc., 2006-2007