Otto Pedraza, Ph.D., is a neuropsychologist with a research focus on the clinical, genetic and psychosocial factors associated with progressive cognitive decline in neurodegenerative and cerebrovascular disorders. In collaboration with colleagues from the areas of neurology, neuroradiology, neuropathology and neurogenetics, Dr. Pedraza seeks to identify novel risk factors associated with cognitive decline, and to improve the diagnostic accuracy and measurement precision of psychometric instruments. Dr. Pedraza is further interested in the role of cultural factors and the influence of health disparities in the clinical manifestation of neurodegenerative and cerebrovascular disorders.
- Exploring the association between cognitive endophenotypes and genetic polymorphisms in neurodegenerative dementias such as Alzheimer's disease and dementia with Lewy bodies
- Identifying and analyzing potential biomarkers to aid in the early detection of dementia prodromes
- Applying advanced statistical methods to identify and mitigate cultural and ethnic disparities in cognitive assessment instruments
- Exploring the impact of small vessel white matter disease on cognitive outcomes in adults with and without obstructive sleep apnea
Significance to patient care
Dr. Pedraza's research activities aim to improve current understanding of the complex relationship between genetic, clinical and sociocultural factors and cognitive outcomes in neurodegenerative diseases. These findings in turn may yield improved accuracy in the early diagnosis of dementia and optimization of potential treatment interventions.