Rochester, Minnesota




Kalyan S. Pasupathy, Ph.D., is an expert in systems science and health informatics and is focused on both advancing the science and translating knowledge to improve care delivery, demonstrated through his academic and practice leadership roles.

Dr. Pasupathy is the founding scientific director of the Mayo Clinic Clinical Engineering Learning Laboratories and has over 15 years of experience leading and pioneering efforts in improving complex care delivery systems. Notably, his work has impacted social service delivery at the American Red Cross and British Red Cross and within health care in nursing, pharmacy, surgery and emergency medicine.

Dr. Pasupathy's team has won awards and created inventions that have been replicated. He has conducted several funded projects, has published over 45 peer-reviewed articles and a book on health informatics, serves as a scholarly reviewer for journals and federal agencies, and is frequently sought to consult or talk internationally.

Focus areas

  • Establishing and leading clinical engineering learning laboratories and directing studies to improve quality of care delivery though operations research, informatics and human factors studies
  • Studying access to health care and implementing policies to improve access in various clinical areas
  • Translating evidence through better prediction and new heuristics within decision support systems; improving surgical utilization and reducing cost
  • Reducing sentinel events by studying human factors and work system patterns
  • Conducting breast cancer research in prediction of treatment effects and post-treatment screening policies
  • Research and teaching simulation, using Simio Academic Software, under a grant from Simio LLC

Significance to patient care

The ability to understand complex systems at the intersection of people, processes and information has led to advancements in improving patient care experience and population health and in achieving desirable outcomes. Dr. Pasupathy's research advances the science and technology at the intersection to transform care delivery systems. His practice translates innovative engineering and informatics principles to improve quality and access and reduce cost of care delivery.

Professional highlights

  • Standing study section member, Agency for Healthcare Research and Quality, 2015-2018
  • Service to Patient-Centered Outcomes Research Institute and National Science Foundation panels, 2008-present
  • INFORMS Innovative Applications in Analytics Award, 2015
  • New Faces of Engineering Award based on innovation, contributions to engineering and significant impact on public welfare, the National Engineers Week Foundation (now DiscoverE), 2009
  • Goodeve Medal, presented at the Royal Society in London, awarded by the Operational Research Society, 2007


See my publications


Administrative Appointment

  1. Senior Associate Consultant II-Research, Division of Health Care Policy & Research, Department of Health Sciences Research

Academic Rank

  1. Associate Professor of Health Care Systems Engineering


  1. Value Measurement for Health Care Harvard Business School
  2. PhD - Concentration: Management Systems Virginia Polytechnic Institute & State University
  3. MS - Concentration: Operations Research Virginia Polytechnic Institute & State University
  4. BE - Concentration: Operations Management Bharathiar University

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