Anders Nykjaer, M.D., Ph.D., studies the effect of sorting receptors on a variety of different neurological disorders, such as Alzheimer's disease, attention-deficit/hyperactivity disorder (ADHD), autism and aberrant neuronal development. The sorting receptors he studies include sortilin, SorLA and SorCS1-3. Using both in vitro and in vivo approaches, Dr. Nykjaer's lab is finding out the particular roles of each receptor, in both health and disease.
Dr. Nykjaer also collaborates within and outside Mayo Clinic to determine the effect of genetic mutations on the functions of these sorting receptors. Additionally, his research group is looking outside the area of neurological disorders to investigate where and how these pivotal proteins play functional roles in human lives.
- SorCS2 proteomics. Dr. Nykjaer's lab investigates the relevance of the characteristic single- and double-chain expression patterns in developing neurons and other cell types.
- SorCS2 genetics. Together with collaborating laboratories, the lab analyzes how single nucleotide polymorphisms in the SORCS2 gene impact a variety of neurological disorders.
- SorLA. The lab also focuses on the relevance of protein sorting by SorLA in neurological disorders.
- SorCS1. The SorCS1 protein and its individual domains are investigated in primarily non-neurological disorders.
Significance to patient care
Abnormal sorting of proteins within neuronal cells seems to be linked to a broad range of disorders, including Alzheimer's disease, ADHD and autism. Exploring the roles of the sorting proteins studied in Dr. Nykjaer's lab will expand the knowledge on how these diseases develop and may lead to novel pathways relevant for early diagnosis and treatment.
- Core group leader, Danish Research Institute of Translational Neuroscience (DANDRITE) Nordic EMBL Partnership for Molecular Medicine, 2013-present
- Chief scientific officer, Insusense Therapeutics, Copenhagen, Denmark, 2013-present
- Director, NeuroCampus Aarhus, Aarhus University, Denmark, 2010-present
- Director, MIND — Membrane Receptors in Neuronal Disease, a Lundbeck Foundation neuroscience center, Aarhus University, Denmark, 2005-present