Rochester, Minnesota


miller.wayne@mayo.edu Clinical Profile


The research interests of Wayne L. Miller, M.D., Ph.D., relate to acute and chronic heart failure and acute coronary syndromes.

Dr. Miller is a Fellow of the American College of Cardiology and the American Heart Association.

Focus areas

  • Ongoing research includes the study of biomarkers, such as cardiac troponins, and natriuretic peptides, such as B-type natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and proBNP, as prognostic markers and indicators of treatment efficacy.
  • Dr. Miller also examines both long-term serial measurements and short-term acute responses to therapy. In addition, he has assessed biomarkers and neurohormones in cardiomyopathy of different etiologies, such as ischemic, idiopathic and amyloidosis.
  • Additional research includes assessment of BNP infusion therapy in acute decompensated heart failure of differing etiologies.
  • Dr. Miller also has a clinical and research interest in intravascular volume assessment and management in patients with chronic heart failure with both reduced and preserved left ventricular ejection fraction. This research has implications in the optimal management of volume overload and congestion in patients with heart failure.

Significance to patient care

Dr. Miller's research program is integrated with clinical research and care for patients in Mayo's outpatient Heart Failure Clinic and inpatient hospital services for heart failure patients.


Primary Appointment

  1. Consultant, Division of Circulatory Failure, Department of Cardiovascular Medicine

Academic Rank

  1. Professor of Medicine


  1. Trainee - Cardiology, Clinical Investigator Program Mayo Graduate School of Medicine, Mayo Clinic College of Medicine
  2. Fellow - Internal Medicine Mayo Graduate School of Medicine, Mayo Clinic College of Medicine
  3. MD Jefferson Medical College, Jefferson University Hospital
  4. Postdoctoral Fellowship - NIH University of Virginia School of Medicine
  5. PhD - Cardiovascular Physiology University of Missouri, Columbia
  6. MS - Veterinary Physiology University of Missouri, Columbia
  7. BA - Zoology - Biological Sciences Slippery Rock University, Pennsylvania State University

Clinical Studies

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