Slobodan I. Macura, Ph.D., applies nuclear magnetic resonance (NMR) spectroscopy and NMR microscopy to the study of biological systems.
- Multidimensional nuclear magnetic resonance of biomolecules to determine their 3-D structure and dynamics in solution
- Techniques for separation of structural and dynamical parameters and structure refinement
- Qualitative and quantitative analysis of metabolites in body fluids and tissue extracts and their relations to the organ or organism status (NMR metabolomics)
- Homonuclear and heteronuclear in vivo NMR spectroscopy
- Homonuclear and heteronuclear NMR spectroscopy of tissue extracts, cell cultures, and perfused organs or tissue
Significance to patient care
NMR is a noninvasive method to study morphology, physiology and biochemistry in various disease models. NMR microscopy in research is the equivalent of magnetic resonance imaging (MRI) in clinical settings. Dr. Macura uses NMR methods to study models of various diseases such as multiple sclerosis, heart failure, polycystic kidney disease and brain tumors. Dr. Macura is also developing new NMR methods to study biological processes.