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The research of Chia-Chen Liu, Ph.D., is focused on understanding why the ε4 allele of the apolipoprotein E gene (APOE) represents a strong risk factor for Alzheimer's disease (AD), whereas APOE2 is protective. Specifically, Dr. Liu investigates the pathogenic pathways by which APOE and age-related risk factors impact the development of AD and cerebral amyloid angiopathy using various genetic disease models and human brain tissues.
Dr. Liu has developed innovative models allowing for inducible and cell-type-specific expression of human APOE isoforms. Using in vivo microdialysis, she also established techniques to measure the dynamic changes of Aβ and other disease-related proteins in the brains of living animals. Dr. Liu's research goal is to establish a foundation for developing mechanism-based therapeutic strategies and treatment for AD.
The ultimate goal of Dr. Liu's work is to contribute to the development of a treatment that successfully mitigates the risk of AD and the design of effective therapies for AD.
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