Brain tumor, breast cancer, colon cancer, congenital heart disease, heart arrhythmia. See more conditions.
Regulation of Cardiovascular Ion Channels
The major focus of our research is to understand the regulation of ion channels in the cardiovascular system. In the heart, ion channel activities regulate the configuration of cardiac action potential, electrical impulse generation and propagation. In blood vessels, ion channels regulate vascular tone and blood flow to organs and tissues. Abnormal ion channel regulation is known to result in cardiac arrhythmias, abnormal blood pressures, and organ perfusion. We use patch clamp and microelectrode techniques to measure action potentials and ionic currents in cardiovascular tissues and cells. We use biochemical and molecular approaches to examine the expression, cellular trafficking, and membrane microdomain targeting of ion channels, and use site-directed mutagenesis techniques to examine structure-function relationships in ion channel regulation.
Specific current research projects include the following:
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