Rochester, Minnesota


LeBrasseur.Nathan@mayo.edu Clinical Profile


Nathan K. LeBrasseur, M.S., Ph.D., studies the genes and signaling pathways influencing skeletal muscle growth and metabolism, and how their manipulation — by genetic alteration, diet, drugs or exercise — affects these physiological processes.

Dr. LeBrasseur examines how beneficial and maladaptive alterations in muscle quantity, quality or both impact muscle performance and physical function as well as metabolic homeostasis.

Focus areas

  • Myostatin (GDF-8). The therapeutic effects of exercise are unmatched; hence, Dr. LeBrasseur and colleagues are exploring what molecular aspects of endurance and resistance exercise should be mimicked or augmented by novel interventions. They have focused on a TGF-beta superfamily member, myostatin (GDF-8), and its blockade as one potential strategy to augment muscle performance in later life as well as a means to improve glucose homeostasis and insulin sensitivity in individuals with type 2 diabetes.

Significance to patient care

Dr. LeBrasseur's goal is to identify safe and effective ways to counter the loss of skeletal muscle with advancing age (sarcopenia) and numerous diseases (cachexia) as a means to improve health span, and to enhance the metabolic properties of muscle to ameliorate type 2 diabetes mellitus and its comorbidities.

Clinical Studies

See my clinical studies


See my publications


Primary Appointment

  1. Consultant, Department of Physical Medicine & Rehabilitation
  2. Consultant, Department of Physiology & Biomedical Engineering
  3. Co-Chair, Research Committee, Department of Physical Medicine & Rehabilitation

Administrative Appointment

  1. Co-Chair for Research, Department of Physical Medicine & Rehabilitation

Academic Rank

  1. Professor of Physical Medicine and Rehabilitation
  2. Associate Professor of Physiology


  1. Ph.D. - Applied Anatomy and Physiology Department of Health Sciences, Boston University
  2. MS - Physical Therapy, with distinction Department of Physical Therapy, Sargent College, Boston University
  3. BS - Health Studies, magna cum laude Department of Physical Therapy, Sargent College, Boston University

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