Location

Phoenix, Arizona

Contact

Joo.HyeMee@mayo.edu

SUMMARY

Solid organ and hematopoietic cell transplantations are radical therapies for fatal conditions. However, post-transplant immune complications, including graft rejection and graft-versus-host disease (GVHD), limit the extended use of these therapies. Current treatment strategies in post-transplantation mainly rely on the use of nonspecific immunosuppressants that can lead to a wide range of adverse effects including cytomegalovirus infections and leukemia relapse.

Dr. Joo's laboratory uses cutting-edge technologies to understand cellular and molecular mechanisms of allograft rejection and GVHD. Dr. Joo's laboratory further investigates how to promote and maintain alloantigen-specific immune suppression in transplantation patients without interfering with host immunity against microbial infections and cancer.

Focus areas

  • Dendritic cell-mediated immune tolerance. Dr. Joo and her colleagues study anti-dendritic cell surface receptors that affect the generation and function of regulatory cells, limiting inflammatory response in human in vitro and animal in vivo transplantation models.
  • Discovery of novel therapeutic targets. Dr. Joo and her colleagues investigate clinically useful therapeutic targets for early diagnosis of post-transplantation rejection.
  • Regulatory B cells and immune tolerance in transplantation patients. Dr. Joo and her colleagues investigate subsets of regulatory B cells that are associated with immune tolerance in transplantation patients.

Significance to patient care

The ultimate goal of Dr. Joo's research is to improve current post-transplantation treatments and diagnostic tools for rejection. Data from these studies will contribute to the rational design of therapeutics for post-transplantation complications.

PROFESSIONAL DETAILS

Administrative Appointment

  1. Associate Consultant I-Research, Immunology, Department of Research

Academic Rank

  1. Assistant Professor of Immunology

EDUCATION

  1. Post Doctoral Fellowship - Immunology Baylor Institute for Immunology Research
  2. PhD - Comparative and Experimental Medicine University of Tennessee
  3. BS - Genetic Engineering Hallym University

Clinical Studies

Learn about clinical trials that address specific scientific questions about human health and disease.

Explore all research studies at Mayo Clinic.

Publications

See the peer-reviewed findings I have published as a result of my research.

Review publications.
.
BIO-20455107

Mayo Clinic Footer