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Yujiro Hayashi, Ph.D., conducts research in the areas of physiology, pharmacology, biochemistry, molecular biology and epigenetics of the gastrointestinal (GI) tract. Dr. Hayashi's current focus is on studying the molecular and epigenetic mechanisms underlying gastric pacemaker stem cell aging.
Age-related gastric dysfunction is associated with anorexia underlying sarcopenia and frailty, but the mechanisms of this dysfunction are incompletely understood. ICC — the pacemaker cells of the gastrointestinal tract — and ICC-SCs decline with age. The research of Dr. Hayashi's lab will determine the molecular and epigenetic mechanisms that drive ICC-SC decline, a putative mechanism of ICC loss and age-related gastric dysfunctions. Data obtained from these studies will provide rationale for discovering new therapeutic targets. Furthermore, Dr. Hayashi's lab will introduce the concept of epigenetic control of gene expression as a novel therapeutic target for preventing decline in gastric function that occurs during aging.
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