Rochester, Minnesota Clinical Profile


Dmitry Esterov, D.O., is the medical director of Mayo Clinic's Traumatic Brain Injury Model System (TBIMS) Research Program, which is a longitudinal multicenter project examining the course of recovery and outcomes following traumatic brain injury (TBI). The TBIMS program conducts research that contributes to evidence-based rehabilitation interventions to improve the lives of individuals with TBI.

Dr. Esterov's research interests also include population-based epidemiology of brain injury and assessing long-term outcomes after TBI. Additionally, he is interested in assessing the health care service value for treatment of acute stroke and research involving mild traumatic brain injury and post-concussion syndrome.

Focus areas

  • Community-based randomized pragmatic clinical trials. Dr. Esterov is a co-investigator on a TBIMS study that seeks to test a model of care that improves access by providing brain rehabilitation resources remotely, including patients in underserved areas of Minnesota, Iowa, North Dakota and South Dakota.
  • Physical activity after TBI. Research has shown that moderate to vigorous physical activity can improve depression, fatigue, insomnia, pain and cognition, all of which are relevant after TBI. Dr. Esterov is researching the effects of physical activity and exercise after TBI in those admitted to acute inpatient rehabilitation after a moderate-severe TBI.
  • Effect of cognitive and physical function on outcome after TBI. TBI affects each individual uniquely, and outcomes are influenced by many factors including injury severity. Outcome prediction after injury is of significant importance because accurate prediction can direct treatment efforts, determine prognosis and shape policy. The purpose of this area of research is to examine differences in outcomes after moderate-severe TBI in individuals with varying degrees of physical and cognitive impairment.

Significance to patient care

Dr. Esterov is part of a team that develops expertise in the design and implementation of community-based randomized pragmatic clinical trials testing complex behavioral interventions. This work seeks to improve outcomes by partnering with state advocacy agencies and incorporating telemedicine. The goal of such studies is to implement successful findings immediately in practice.


See my publications


Primary Appointment

  1. Senior Associate Consultant, Department of Physical Medicine & Rehabilitation


  1. BASIC SCIENCE MASTERS Clinical and Translational Science, Programs, Mayo Graduate School, Mayo Clinic College of Medicine
  2. Masters of Clinical Research - Quantitative Sciences Clinical and Translational Science, Programs, Mayo Graduate School, Mayo Clinic College of Medicine
  3. Fellow Brain Injury Rehabilitation Medicine Fellowship, Programs in Rochester, Mayo Clinic School of Graduate Medical Education
  4. Resident - Physical Medicine and Rehabilitation JFK Johnson Rehabilitation Institute
  5. Internship Maimonides Medical Center
  6. Doctor of Osteopathic Medicine Rowan University
  7. BA - Bachelor of Arts, Major in English Literature Cum Laude The College of New Jersey

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