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The Comparative Pathogenesis of Alzheimer's Disease and Related Disorders Laboratory led by Casey N. Cook, Ph.D., is focused on identifying common pathological mechanisms across a spectrum of disorders. In particular, the overall goal of the laboratory is to provide new insight into pathogenic mechanisms of Alzheimer's disease (AD) and related disorders and elucidate novel therapeutic strategies to treat them. To achieve these goals, the lab uses cell and animal models, as well as human biofluids and postmortem tissue samples.
The lack of effective treatments for most neurodegenerative diseases makes their diagnosis particularly devastating to patients. To address this need and facilitate the discovery of novel treatment strategies and biomarkers, Dr. Cook's research is focused on understanding the underlying causes of neurodegeneration. In particular, by mapping specific molecular routes that lead to AD and related disorders, effective strategies to detour disease progression can be identified, with key landmarks providing ideal targets for biomarkers of disease status.
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