Rochester, Minnesota


Cleary.Sean@mayo.edu Clinical Profile


Sean P. Cleary, M.D., is a surgeon-scientist with a clinical and research focus on hepatobiliary and pancreatic surgical oncology. Dr. Cleary's research on genetic epidemiology investigates how genetic factors affect liver cancer and pancreas cancer. Dr. Cleary has led several studies on the clinical management of these diseases, including involvement in multinational and multicentered clinical trials. Dr. Cleary also has had long-term collaborations with and involvement in large population-based cancer genomics studies funded by the National Institutes of Health (NIH).

Focus areas

  • Minimally invasive liver surgery
  • Minimally invasive pancreas surgery
  • Pancreas cancer
  • Genetic epidemiology, genomics and clinical management of hepatocellular carcinoma
  • Genetic epidemiology of pancreas cancer

Significance to patient care

Dr. Cleary's research evaluates how genetic alterations in cancers determine their behavior and response to therapy. Dr. Cleary's research also examines genetic factors that increase cancer predisposition. Gaining a better understanding of cancer genetics may ultimately lead to improved treatment options for patients.

Professional highlights

  • Americas Hepato-Pancreato-Biliary Association (AHPBA)
    • President, 2023-2024
    • President-elect, 2022-2023
    • Secretary, 2020-2022
    • Gazi Zibari Global Outreach Humanitarian Award, 2019
    • Chair, International Relations Committee, 2013-2016
    • Board member, AHPBA Foundation, 2010-2013
  • Mayo Clinic Comprehensive Cancer Center
    • Co-deputy director, Disease Groups, 2022-present
    • Chair, Hepatobiliary and Pancreatic Disease Groups, 2021-present
  • Canadian Association of General Surgeons
    • President, 2020-2022
    • President-elect, 2018-2020
    • Treasurer, 2015-2018
    • Chair, Program Committee, Canadian Surgical Forum, 2008-2013
  • Chair, Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, 2019-present
  • Surgical Specialty Society Governor, Board of Governors, American College of Surgeons, 2017-present
  • Fellow, American College of Surgeons, 2012-present
  • Chair, Liver Site-Group Tissue Committee, University Health Network Tissue Bank, 2007-2017
  • Nicholas Colapinto Teaching Award, University of Toronto, 2014, 2016
  • President, Canadian Hepato-Pancreatico-Biliary Association, 2007-2015


Primary Appointment

  1. Division of Hepatobiliary and Pancreas Surgery, Department of Surgery
  2. Division of Hepatobiliary and Pancreas Surgery, Department of Surgery
  3. Disease Groups, Mayo Clinic Comprehensive Cancer Center

Academic Rank

  1. Professor of Surgery


  1. Masters - Masters of Public Health, Community Health & Epidemiology University of Toronto, Dalla Lana School of Public Health Sciences
  2. Fellow - Hepatobiliary Oncology and Transplantation Surgery Toronto General Hospital, University of Toronto
  3. Residency - General Surgery University of Toronto
  4. Master of Science - Clinical Investigator Program Institute of Medical Science, University of Toronto
  5. MD University of Western Ontario
  6. BSc (Hons) - Life Science Queens University

Clinical Studies

Learn about clinical trials that address specific scientific questions about human health and disease.

See my studies.

Explore all research studies at Mayo Clinic.


See the peer-reviewed findings I have published as a result of my research.

Review publications.

Mayo Clinic Footer