Garret W. Choby, M.D., is a fellowship-trained rhinologist and endoscopic skull base surgeon practicing at Mayo Clinic, where he also serves as the chair of quality in the Department of Otolaryngology — Head and Neck Surgery.
Dr. Choby's primary research interests include tailoring individualized treatment for patients with chronic rhinosinusitis and improving oncologic and quality-of-life outcomes of endoscopic endonasal skull base tumor surgery.
Assessing and improving quality of life after endoscopic skull base surgery. Clinicians are increasingly able to tackle larger and complex skull base tumors via endoscopic endonasal approaches. Dr. Choby is focused on optimizing quality-of-life outcomes for patients after such surgery.
He also has an ongoing interest in skull base reconstruction and minimizing postoperative sequelae in patients undergoing these procedures. He is involved in collaborative studies with other leading institutions examining postoperative olfaction, chemosensory disturbances and improving methods to minimize sinonasal morbidity.
- Understanding survival differences in sinonasal cancer. Dr. Choby is particularly interested in pathologies including sinonasal mucosal melanoma and olfactory neuroblastoma (esthesioneuroblastoma). His research is focused on genomic and transcriptomic profiling of sinonasal mucosal melanoma and understanding tumor recurrence implications of histopathologic features of esthesioneuroblastoma.
Chronic rhinosinusitis and aspirin-exacerbated respiratory disease (AERD) outcomes. Dr. Choby is involved in numerous ongoing projects at Mayo Clinic and in collaboration with other leading institutions, aimed at better understanding how to improve patient quality of life after endoscopic sinus surgery.
In addition, he is interested in the fundamental mechanisms of chronic activation of immune cells, which lead to the development of chronic rhinosinusitis and nasal polyposis. He is particularly interested in AERD and is conducting prospective evaluations and biomarker investigations to better understand the role of T cell dysregulation in AERD. Dr. Choby works collaboratively with Hirohito Kita, M.D., and Kathleen R. Bartemes, Ph.D., in Mayo Clinic's Allergic Diseases Research Laboratory on these investigations.
- Quality improvement. As the chair of quality in the Department of Otolaryngology — Head and Neck Surgery, Dr. Choby has a keen interest in various aspects of quality improvement. Particular areas of interest include physician well-being and burnout, patient perception of health care quality, and optimizing pain control after surgery while minimizing narcotic requirements.
Significance to patient care
Dr. Choby's overall research goal is to develop the most-effective treatments for patients undergoing treatment for skull base tumors, chronic rhinosinusitis and AERD.