Rochester, Minnesota


callstrom.matthew@mayo.edu Clinical Profile


Matthew R. Callstrom, M.D., Ph.D., is a consultant in the Division of Diagnostic Radiology at Mayo Clinic and a professor of radiology at Mayo Clinic College of Medicine. Dr. Callstrom's research is centered on interventional oncology.

Focus areas

  • Percutaneous ablation. A significant area of focus involves the use of percutaneous ablation methods for treating cancer in the liver, kidney, bone, lung and soft tissue. As part of this effort, Dr. Callstrom's research team has conducted several clinical trials to evaluate the effectiveness of both radiofrequency ablation and cryoablation for palliation of painful metastases involving bone. Three ongoing trials will determine whether cryoablation is beneficial for the treatment of focal painful metastatic disease for patients that have failed conventional therapies, compare the effectiveness of cryoablation with radiation therapy for patients that present with painful metastases, and determine the effectiveness of both radiofrequency ablation and cryoablation for stimulation of a systemic immunological response to metastatic melanoma.
  • Image fusing. An additional area of interest is the development of image fusion of previously acquired CT, MRI or PET imaging with real-time ultrasound imaging. This research involves acquisition of 3-D volumes of ultrasound data linked to a magnetic position sensor for correlation with the real-time imaging, image fusion and registration, and development of tools for biopsy and ablation using fusion imaging.

Significance to patient care

Dr. Callstrom's research contributes to the development of technologies that will allow better identification and treatment of cancer in the liver, kidney, bone, lung and soft tissue as well as indeterminate lesions in the liver and kidney.

Professional highlights

  • Editor's Honorees: Clinical Studies, Journal of Vascular and Interventional Radiology, 2012
  • Exemplary mentor certificate, Claremont Graduate University, 2011
  • Magna cum laude, Radiological Society of North America, 2011
  • Outstanding faculty award, Society of Interventional Radiology, 2010
  • Lodwick Award, Musculoskeletal Imaging & Intervention Division, Department of Radiology, Massachusetts General Hospital, Harvard University, 2008


Primary Appointment

  1. Consultant, Department of Radiology

Administrative Appointment

  1. Chair, Department of Radiology

Academic Rank

  1. Professor of Radiology


  1. MD Whitney MacMillan Physician Leadership Business Academy The Realities of Business, Finance and Strategic Acumen, Arizona State University WP Carey School of Business
  2. Fellow - Cross-sectional Imaging Department of Radiology
  3. Resident Diagnostic Radiology, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  4. Resident - Diagnostic Radiology Mayo Graduate School of Medicine, Mayo Clinic College of Medicine
  5. MD Mayo Medical School, Mayo Clinic College of Medicine
  6. Post Doctoral Fellowship - George M. Whitesides, advisor Harvard University
  7. PhD - Chemistry - Paul G. Gassman, advisor University of Minnesota, Twin Cities
  8. BS - Chemical Engineering University of Minnesota, Twin Cities

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