Jacksonville, Florida


burger.charles@mayo.edu Clinical Profile


Charles D. Burger, M.D., studies the clinical presentation, evaluation and treatment of pulmonary hypertension and lymphangioleiomyomatosis. The long-term goal of Dr. Burger's research is to promote earlier diagnosis, more accurate assessment of disease state, and more effective treatment for patients with either pulmonary hypertension or lymphangioleiomyomatosis.

Dr. Burger's team makes extensive use of Mayo Clinic clinical and national multicenter databases that characterize these two diseases. Ongoing treatment trials have been established for both pulmonary hypertension and lymphangioleiomyomatosis.

Dr. Burger's research has been funded by the National Institutes of Health, Mayo Clinic and the Department of Defense, among other organizations.

Focus areas

  • What is the most appropriate testing for a patient with pulmonary hypertension? Dr. Burger is working to better understand how clinical presentations and pre-test probability should influence the medical evaluation of patients with pulmonary hypertension — specifically, the utility of screening for co-existing diseases that may influence pulmonary hypertension and the use of echocardiography and cardiac MRI to better prognosticate.
  • How do clinicians best treat pulmonary hypertension? Dr. Burger's team is examining the impact of different medications and combinations thereof on clinical symptoms and disease state.
  • How do scientists determine patients' responses to treatment and prognosis? Ongoing research by Dr. Burger's team has contributed to the development of risk factor scoring tools such as the Registry to Evaluate Early and Long-Term PAH Disease Management (REVEAL) 2.0 risk score and has produced meaningful results from specialized testing.
  • How do we best treat lymphangioleiomyomatosis? Dr. Burger's team is examining the impact of medications approved for other diseases but not studied in patients with lymphangioleiomyomatosis.
  • What is the mechanism of lung disease in lymphangioleiomyomatosis? Dr. Burger has been involved in the study of the pathophysiological mechanisms of obstructive lung disease in patients with lymphangioleiomyomatosis.

Significance to patient care

Dr. Burger's research into the areas described above may potentially streamline the evaluation process and identify more effective treatments for patients with either pulmonary hypertension or lymphangioleiomyomatosis.

Professional highlights

  • Associate medical director, Mayo Clinic Office of Clinical Trials, 2015-2020
  • Distinguished educator, Mayo Clinic College of Medicine and Science, 2019
  • Editor-in-chief, Advances in Pulmonary Hypertension, 2015-2017
  • Member, Scientific Leadership Council, Pulmonary Hypertension Association, 2010-2016
  • Distinguished clinician, Mayo Clinic, 2014
  • Board member, National Association for Medical Direction of Respiratory Care, 1999-2002
  • President, Florida Society of Critical Care Medicine, 1998


Primary Appointment

  1. Consultant, Division of Pulmonary Medicine, Department of Internal Medicine

Academic Rank

  1. Professor of Medicine


  1. Fellowship - Pulmonary and Critical Care Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic College of Medicine and Science
  2. Resident Pulmonary Diseases, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. Internship/Residency - Internal Medicine Vanderbilt University Hospital
  4. MD Bowman Gray School of Medicine
  5. MD University of Tennessee Center for the Health Sciences
  6. BA - Chemistry University of Tennessee, Knoxville
  7. BA Carson-Newman College

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