Brain tumor, breast cancer, colon cancer, congenital heart disease, heart arrhythmia. See more conditions.
The research foundation of Alexey E. Alekseev, Ph.D., evolved from the concept that the failing heart is an engine out of fuel. In this regard, energy-sensing KATP channels were recognized as a peripheral bidirectional regulator of muscle energy expenditure, which may find implication in a range of energy imbalance conditions linked to heart failure, obesity and cold intolerance.
The research contributions of Dr. Alekseev focus on investigating the molecular cardioprotective mechanisms controlling cellular energy homeostasis. These mechanisms can provide a basis for rational prognosis, diagnosis and development of preventive therapies to restore energy metabolism (such as under obesity), mitigate cardiomyopathy and the progression of heart failure.
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