Deep brain stimulation

This collaborative clinical research group focuses on identifying potential mechanisms of action of deep brain stimulation (DBS), given the favorable neuropsychologic and psychiatric outcomes observed among patients with Parkinson's disease. Areas of study include neural circuitry, neurotransmission and synaptic plasticity.

Functional neuromodulation, such as deep brain stimulation, offers opportunity for surgical treatment of refractory psychiatric disorders. Several therapeutic trials have been conducted to investigate the effectiveness of DBS in the treatment of refractory depression, obsessive-compulsive disorder and Tourette syndrome.

Currently the group is part of a multicenter, controlled trial of deep brain stimulation for obsessive-compulsive disorder. Future plans include a clinical trial of deep brain stimulation for treating refractory depression.


  • Osama A. Abulseoud, M.D., is studying the impact of comorbid alcoholism on mania phenotypes and has successfully induced manic-like behavioral phenotypes in two types of rats. He has also identified a novel mechanism of action of DBS in reducing ethanol consumption through regulation of circadian rhythm genes in the nucleus accumbens.
  • Clinically, the group is studying the impact of emotional or behavioral induction during subthalamic DBS parameter optimization in patients with Parkinson's disease. This includes effect on mood disorders and overall quality of life.



Investigator & Role Grant Title Funding Source Duration
Osama A. Abulseoud, M.D., principal investigator Preclinical Glutamate Modulation Through Deep Brain Stimulation as a Novel Target for Alcohol Addiction Mayo Clinic Center for Translational Science Activities KL2 Mentored Career Development Award 07/2011-06/2014


See publications by deep brain stimulation researchers on PubMed:

DBS-related papers

Non-DBS related papers