Infectious Diseases Research

Below are current clinical trials.

259 studies in Infectious Diseases Research
(all studies, either open or closed).

Filter this list of studies by location, status and more.

1. A Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia (enrollment by invitation only)

   Rochester, Minn.

   The purpose of this study is to evaluate the efficacy, safety, pharmacodynamics, and pharmacokinetics of tocilizumab (TCZ) compared with a matching placebo in combination with standard of care (SOC) in hospitalized patients with severe COVID-19 pneumonia.

2. COVID-19 Serological Assay Validation

   Rochester, Minn.

   The purpose of this research is to evaluate multiple new tests for detection of antibodies to SARS-CoV-2, the cause of COVID19, in blood samples.

3. A Study to Generate Algorithms for Early Prediction of Aggressive Progression and Hospitalization in Patients Diagnosed with SARS-CoV-2/COVID-19 Infection

   Rochester, Minn.

   The purpose of this study is to observe participants who have tested positive for COVID-19 using Current Health AI to learn about the disease.

4. A Study of VE303 for Prevention of Recurrent Clostridium Difficile Infection

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to evaluate the safety and effectiveness of VE303 for participants with primary C. difficile infection (pCDI) at high risk for recurrence or subjects with recurrent C. difficile infections (rCDI).

5. Mucosal and Microbiota Changes During Acute Campylobacteriosis

   Rochester, Minn.

   Gastrointestinal (GI) infection with Campylobacter causes inflammation in the bowel and can change bacteria in the gut. Certain individuals with Campylobacter infection are also known to develop chronic bowel problems such as Irritable Bowel Syndrome (IBS). The researchers are doing this study to understand if changes in gut bacteria and gut mucosal lining during an acute infection can help identify individuals who might be at risk for developing problems in the future.

6. A Study to Evaluate the Safety of the SARS-CoV-2 Vaccination in Patients Waitlisted for Solid Organ Transplantation

   Jacksonville, Fla.

   The purpose of this study is to determine the safety of the SARS-CoV-2 vaccination in patients listed for solid organ transplantation, including heart, lung, liver, kidney, and pancreas.

    

7. Cellular Senescence and COVID-19 Long-Hauler Syndrome

   Rochester, Minn.

   The purpose of this study is to test if senescent cells and their secretome contribute to Long-Hauler Syndrome and if a clinical trial of senolytic drugs, which selectively eliminate senescent cells, should be initiated. 

8. Presatovir In Hematopoietic Cell Transplant Recipients With Respiratory Syncytial Virus (RSV) Infection Of The Lower Respiratory Tract

   Scottsdale/Phoenix, Ariz.

   This study will evaluate the effect of presatovir on respiratory syncytial virus (RSV) viral load in autologous or allogeneic hematopoietic cell transplant (HCT) recipients with an acute RSV lower respiratory tract infection (LRTI), the effect of presatovir on being free of any supplemental oxygen, and rates of respiratory failure and all-cause mortality, and pharmacokinetics (PK), safety, and tolerability of presatovir.

9. A Study To Evaluate The Safety And Effectiveness Of Antithrombotics To Treat Hospitalized COVID-19 Patients

   Scottsdale/Phoenix, Ariz.

   This is a randomized, open label, adaptive platform trial to compare the effectiveness of antithrombotic strategies for prevention of adverse outcomes in COVID-19 positive inpatients