Infectious Diseases Research

Below are current clinical trials.

273 studies in Infectious Diseases Research
(all studies, either open or closed).

Filter this list of studies by location, status and more.

1. A Study of CB-183,315 in Patients With Clostridium Difficile Associated Diarrhea

   Rochester, Minn.

   608 patients with Clostridium Difficile Associated Diarrhea (CDAD) will participate in this study and receive either oral vancomycin or CB-183,315 in a blinded fashion. Treatment will last for 10 days and participants will be followed up for at least 40 days and a maximum of 100 days. The purpose of this study is to evaluate how well CB-183,315 treats CDAD as compared to vancomycin.

2. An Open Label Study to Examine the Effects of DAS181 Administered by Dry Powder Inhaler (DPI) or Nebulized Formulation in Immunocompromised Subjects With Parainfluenza (PIV) Infection

   Scottsdale/Phoenix, Ariz.

   This protocol will seek to enroll up to 60 immunocompromised subjects diagnosed with parainfluenza infection.

   All subjects will have additional PK and Immunogenicity blood samples collected.

3. Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine

   Rochester, Minn.

   The purpose of this study is to evaluate approximately 15,000 health care workers at risk for being exposed to COVID-19. 

4. Losartan for Outpatients on COVID-19

   Rochester, Minn.

   This is a multicenter randomized controlled trial comparing losartan vs placebo for outpatients with COVID. Every patient that is tested in the ED and drive through clinic will receive a brochure with information about the study. COVID positive will be called, and will receive supplies (medication, thermometer and swabs) at home.

5. Trials Evaluating Oral Full-Spectrum Microbiota™ (CP101) in Subjects with Recurrence of Clostridium difficile Infection

   Rochester, Minn.

   The purpose of this study is to evaluate the safety and effectiveness of CP101 treatment in adults who had a Clostridum difficile Infection (CDI) recurrence within 8 weeks of receiving CP101 or placebo.

    

6. Molecular Analysis of Blood for the Detection of Cardiovascular Pathogens

   Rochester, Minn.

   The purpose of this study is to test whether metagenomic shotgun sequencing can identify pathogens causing cardiovascular infections such as infective endocarditis or myocarditis.

7. A Study of Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection on Vancomycin Resistant Enterococci Status of Patients

   Rochester, Minn.

   The purpose of this study is to evaluate if Vancomycin Resistant Enterococci (VRE) can be eradicated in patients with Clostridium Difficile infection (CDI) through treatment with Fecal Microbiota Transplantation (FMT) when FMT is being done to treat recurrent CDI rather than VRE.

    

8. Long Term Prognosis of Neuroinvasive West Nile Infection

   Rochester, Minn.

   The purpose of this study is to assess short and long term outcomes and factors related to poor prognosis in patients with neuroinvasive West Nile disease

9. Evaluation of De-escalated Adjuvant Radiation Therapy for Human Papillomavirus (HPV)-Associated Oropharynx Cancer

   Rochester, Minn., La Crosse, Wis., Eau Claire, Wis., Scottsdale/Phoenix, Ariz.

   This study is designed for patients with a cancer of the oropharynx (tonsils or base of tongue) caused by the HPV virus. Traditional treatment involves surgery followed by six weeks of daily radiation therapy. This study investigates a less intense radiation treatment following surgery that uses half the dose of radiation given over two weeks rather than six weeks. Patients will be randomly assigned to receive the less intense treatment versus the traditional treatment by coin flip. Patients are twice as likely to receive the less intense treatment during randomization.

10. A Study to Evaluate the QuantiFERON-TB Gold-Plus Test for Blood Detection of Tuberculosis without Symptoms

    Rochester, Minn.

    The purpose of this study is to evaluate the new QFT-Plus assay compared to the QFT-Gold assay and the tuberculin skin test results (as available) for the detection of tuberculosis without symptoms in high-risk patients.