Nuclear Magnetic Resonance (NMR) Core Facility

The Nuclear Magnetic Resonance (NMR) Core Facility helps Mayo Clinic investigators apply high-field NMR to biochemical and biological systems.

The facility contains high-field state-of-the-art NMR spectrometers for data acquisition, computers for NMR data analysis and a fully equipped wet laboratory for sample preparation. Instrumentation includes the following:

  • Bruker DRX-300 (300 MHz) with microimaging equipment for small animal MRS and MRI at 7 Tesla
  • DRX-500 (500 MHz)
  • DRX-600 (600 MHz) with cryoprobe
  • DRX-700(700 MHz) with microimaging equipment for small animal MRS and MRI at 16.4 tesla
  • DRX-700WB (700 MHz) with cryoprobe

The facility is fully equipped for in vivo (small animals) and ex vivo (organs, tissue and specimens) magnetic resonance spectroscopy (1H, 13C and 31P) and MRI and microscopy at magnetic fields of 7 and 16.4 Tesla.

In addition to high-field MRS and MRI, techniques include multinuclear and multidimensional high-resolution spectroscopy of small molecules, such as those in body fluids, tissue extracts, drugs and so on, and macromolecules, such as in proteins, DNA, protein complexes and so on.

NMR is mature technology, driving scientific advances in many areas of biomedical research and enabling novel approaches to old questions and posing new questions. The NMR Core Facility serves collaborative, interdisciplinary research providing tools and expertise to Mayo researchers to solve problems whose solutions are amenable to NMR.