James R. Thompson, Ph.D.

James R. Thompson, Ph.D.

James R. Thompson, Ph.D., an expert protein biochemist and X-ray crystallographer, serves as director of the X-ray Crystallography Core. Half of his time is dedicated to this role.

Within the core, Dr. Thompson's responsibilities include:

  • Overall administration, repair and maintenance needed to sustain a state-of-the-art core
  • Hands-on teaching and mentorship throughout projects related to macromolecular X-ray crystallography
  • Performing crystallography for collaborations, but only if rewarding, required and when core effort is available

In December 2003, Dr. Thompson established the first fully equipped crystallography laboratory at Mayo Clinic. Between 2003 and 2011, he formed 52 separate collaborative projects involving — or likely soon to be employing — crystallography with 19 principal investigators.

Dr. Thompson is also co-principal investigator and co-director for crystallography-related infrastructure provided by two Minnesota Partnership for Biotechnology and Medical Genomics grants. This crystallography infrastructure is located at both Mayo Clinic and the University of Minnesota.

His personal research interests include the structure and function of lipoprotein assembly and transport, lipid metabolism, DNA repair and regulation of transcription, and structural-guided drug discovery using a fragment-based method.

Dr. Thompson is a senior associate consultant in the Department of Physiology and Biomedical Engineering at Mayo Clinic and an assistant professor of biophysics in the College of Medicine, Mayo Clinic.