The Proteomics Core at Mayo Clinic provides basic scientists and clinician-investigators with consultations, technologies and services for the analysis of proteins from tissues, cells or biological samples. By utilizing current and innovative proteomics techniques, the core advances scientific knowledge of disease biogenesis and contributes to improved patient care.

The core applies proteomics — the analysis and identification of proteins — for applications that include:

  • Elucidating new disease biomarkers
  • Improving the understanding of disease mechanisms, such as cancer
  • Determining dominant epitopes in autoimmune disorders
  • Developing more-effective peptide-based vaccines and drugs
  • Creating new diagnostic tests for clinicians at Mayo Clinic

Proteomics Core staff members are available to meet with investigators and research teams to provide advice and consultation regarding project design and discuss effective implementation of core services. Additionally, the core provides letters of support, documentation and methodology information for grant applications that include some aspect of protein analysis.

Recent projects in the Proteomics Core are focused on identifying the key proteins in:

  • Colon, lung and prostate cancer
  • Polycystic kidney disease
  • Heart failure
  • Preeclampsia
  • Thyroiditis and other autoimmune diseases
  • Osteoporosis
  • Alzheimer's disease
  • Obesity
  • Light chain amyloidosis
  • Nerve regeneration