In January 2013, the Flow Cytometry/Optical Microscopy Core (established in 1987) merged with the Electron Microscopy Core (established in 1959) to form the Microscopy and Cell Analysis Core (MCAC).

In addition to being a Mayo Clinic research core, the MCAC is part of the Mayo Clinic Cancer Center, which is a National Cancer Institute-designated comprehensive cancer center. The core also has strong ties with Mayo clinical departments, including the Department of Laboratory Medicine and Pathology and Mayo Medical Laboratories.

The Microscopy and Cell Analysis Core occupies more than 5,000 square feet, with offices and main lab space located in the Guggenheim Building on the 14th floor at Mayo Clinic's campus in Rochester, Minnesota. Personnel include 24 full-time staff members, most of whom have more than 25 years of laboratory experience.