DNA molecule model


Mayo Clinic serves as a leader in genomic analyses for Mayo Clinic investigators and medical researchers around the world advancing the understanding of human disease, improving health and promoting excellence in patient care. To accomplish this, the Genome Analysis Core provides a broad range of genomic services with expert consultation, customized support, access to state-of-the-art technologies and the highest quality data.

The Genome Analysis Core, led by co-directors Eric D. Wieben, Ph.D., and Julie M. Cunningham, Ph.D., provides consultations to help investigators achieve their research objectives. Services in the core support patient care by providing a discovery portal through which clinically relevant findings may be brought into routine clinical practice. Genomic analyses allow clinicians and researchers to learn about differences and changes in an individual's genetic makeup, leading to discovering the role that genetics plays in disease and treatment.

The Genome Analysis Core offers a full range of both short-read (Illumina) and long-read (Pacific Biosciences) next-generation sequencing, gene expression, genotyping and DNA methylation applications, including:

  • Library preparation for Illumina, PacBio and 10X single cell sequencing
  • Whole-genome sequencing
  • Whole-genome methylation
  • Whole transcriptome (RNA Seq)
  • Targeted sequencing (QiaSeq, Agilent)
  • Small RNA (microRNA)
  • Reduced representational bisulfite sequencing (RRBS)
  • Microarrays for genome-wide genotyping (Illumina Infinium)
  • Sample Identification Validation (SIDV)
  • 10X Genomics single cell analyses
  • No-Amp CRISPR/Cas-9 Targeting (PacBio)
  • Iso-Seq (PacBio)

DNA or RNA from multiple sources may be analyzed including fresh-frozen tissues, formalin-fixed, paraffin-embedded (FFPE) tissues, laser-capture micro-dissected cells and cell lines.

The Genome Analysis Core provides services to all Mayo Clinic faculty and staff engaged in research. Additionally, services are offered to investigators and research collaborators outside Mayo Clinic. For more information or to schedule a consultation, please contact the core.