Illustration of a helix.


The Genome Analysis Core's Gene Expression Service Line, part of the Medical Genome Facility in the Center for Individualized Medicine at Mayo Clinic, provides comprehensive services and technical support for the measurement of gene expression in clinical and nonclinical samples. The service line supplies customers both inside and outside Mayo Clinic.

The Gene Expression Service Line utilizes multiple state-of-the-art platforms — including microarray-based technologies from Affymetrix, Illumina and Agilent, and quantitative polymerase chain reaction (qPCR) instrumentation from Fluidigm and Applied Biosystems — for a variety of gene expression analyses.

Services are also available for sample preparation for whole-genome messenger RNA (mRNA) and microRNA (miRNA) profiling by next-generation sequencing. The Gene Expression Service Line currently provides whole-transcriptome and miRNA expression analyses of RNA derived from fresh-frozen tissues; formalin-fixed, paraffin-embedded tissues; laser-capture microdissected cells; and cell lines.